Vitamin D3 Deficiency? 25-OH vitamin D level

Vitamin D3, 25-OH test

Vitamin D is important for the human body. It makes bones stronger and has a positive effect on mood.
However, many people suffer from vitamin D deficiency. They eat too few foods containing this vitamin and do not get enough contact with sunlight. In fact, vitamin D can not only be ingested, it can also be produced in the body under the influence of sunlight. Vitamin D deficiency can weaken bones. It can also lead to a dejected mood.

This test measures the amount of vitamin D in blood. Two different forms occur in the blood: the active form 1,25-dihydroxy vitamin D and the inactive form 25-hydroxy vitamin D that serves as a store of the active form.

Vitamin D, is one of the few vitamins our body can make itself. Under the influence of sunlight (ultraviolet radiation), vitamin D is formed in our skin and converted to an active form in the liver and kidneys. However, these amounts are not sufficient for all people, nor under all circumstances. Therefore, we often need additional vitamin D from our diet. Oily fish such as eel, herring, salmon, mackerel and bokking, for example, contain a lot of vitamin D.

We need vitamin D for strong bones and teeth. It allows calcium and phosphate from our diet to be absorbed and deposited in our bones, teeth and molars during growth. In addition, vitamin D is needed to minimize osteoporosis (osteoporosis).

Some people do not get much, if any, daylight, for example, night workers, people with dark skin tones or people who cover their skin completely. They are at risk of vitamin D deficiency.

Lowered:
A low vitamin D in the non-active form (25-hydroxy vitamin D) indicates a vitamin D deficiency. This can be caused by too little sunlight, insufficient dietary intake or poor absorption from the intestines. Low vitamin D in the active form (1,25-dihydroxy vitamin D) can occur with kidney disease. The use of some medications for epilepsy may result in a less functioning liver, causing it to produce less vitamin D. Insufficient magnesium can lead to decreased calcium levels. The body cannot repair this with vitamin D and parathyroid hormone (PTH). After administration of magnesium and calcium, regulation is restored.

Vitamin D is produced in the skin, however, sunlight must have a certain intensity. If the shadow of the body is longer than the actual body height, the body is no longer able to produce vitamin D itself. In addition, vitamin D can be obtained from food (fatty fish, shiitake mushrooms, egg yolk and cooking fats) or from vitamin D pills. The variant from plants is the D2 variant but is converted to the active metabolite in the body as much as the D3 from animals. As an indication of the relationship vitamin D intake (cholecalciferol) and measured concentration, approximately 1 microgram/day for each nmol/l increase can be maintained. To go from 50 to 80 nmol/l 25(OH)D requires about 30 micrograms of cholecalciferol per day for at least two months.

Below a (25(OH)) D serum concentration of 20 nmol/l, the risk of rickets and osteomalacia is greatly increased (multiple publications).

• Muscle pain and symptoms occur at concentrations < 20 nmol/l (ref. Torrentes de la Jara), while muscle weakness and increased risk of falls occur at concentrations < 50 nmol/l (Janssen/Verhaar, Lips, Bischoff-Ferrari)
• Bone density decreases significantly at values < 50 nmol/l (e.g., Bischoff-Ferrari)
• By aiming for a minimum level of 75-80 nmol/l, gains can be made through risk reduction for multiple types of cancer and for autoimmune diseases (Dawson-Hughes, Biscchoff-Ferrari et al.)
• One must move to even higher values (> 100 nmol/l) for special results such as lowering the incidence of seizures in MS
• Up to a concentration of about 220 nmol/l, there is no danger of excessive calcium

Elevated:
A high vitamin D in the non-active form (25-hydroxy vitamin D) usually means a person is getting too much vitamin D, such as through vitamin pills or other supplements. High vitamin D in the active form (1,25-dihydroxy vitamin D) can come from excessive production of parathyroid hormones or in diseases such as sarcoidosis or some lymphomas.
High vitamin D (concentrations above 250 nmol/l) combined with elevated calcium can cause calcification and damage to organs such as the kidneys. The body tries to reduce the amount of calcium by depositing calcium phosphate in the organs. This causes the organs to calcify and become damaged.

How to solve a vitamin D3 deficiency
First, a blood test measuring the D3. If it is below the minimum value of 80 nmol/l, it is wise to take a supplement. If the value is below 40 nmol/l it is advisable to ask the doctor for Cholecalciferol, a liquid form of D3, in high doses and reimbursed by the health insurance company.

It is important to keep measuring the D3 value regularly so that you do not get too high a level.

Also read our blog: https: //info.bloedwaardentest.nl/jouw-vitamine-d-spiegel-hoog-genoeg/