pseudocholinesterase gene disorder anesthesia
In this blood test, 3 tests are performed to measure whether you have this hereditary gene defect tw:
- Dibucaine number
Are you genetically predisposed to not being able to break down some anesthetics and muscle relaxants?
Do you perhaps have a pseudocholinesterase deficiency? If so, report this before you have to undergo anesthesia.
Butyrylcholinesterase is also known by the name, pseudocholinesterase or plasma cholinesterase.
The test determines the activity of the enzyme pseudocholinesterase. This enzyme is closely related to cholinesterase or acetylcholinesterase. Acetylcholinesterase is produced in nerve cells and is important for the breakdown of the nerve stimulating substance (neurotransmitter) acetylcholine in the nerve endings. Degradation of acetylcholine stops nerve stimulation until a new stimulus is produced via newly released acetylcholine.
The related enzyme pseudocholinesterase (also called acylcholinesterase or cholinesterase II) is not produced in the nerves, but in the liver. It is less specific than the cholinesterase itself. The role of pseudocholinesterase in the body is not clear there are no known diseases related to the activity of the enzyme. However, it has been shown that a lowered activity of pseudocholinesterase can be a clue to explain certain phenomena. For example, lower enzyme activity causes certain muscle relaxant drugs to work much longer than expected. This is because the lowered enzyme activity delays the breakdown of the active ingredient (succinylcholine) in the drug.