Pyridinoline, deoxypyridinoline in urine
Crosslinks in urine. (10 ml Pyidionolin (PYD) (PYRIU PYRICR tube shield with aluminum foil against light)
Synonyms pyridinoline, deoxypyridinoline in urine, Pyridinoline in urine
This test here says bone metabolism.
Collect urine up to about 9:00 a.m. Second morning urine, aluminum foil around the tube against light.
The N-telopeptide and creatinine are used to calculate the ratio of N-telo to Creatinine: This ratio referred to as "NTx".
This test can be done at:
1. Women in menopause, not receiving hormone replacement therapy(HST): Women with a baseline NTx value higher than 38 have a significant risk of a decrease in bone mineral density
(BMD= Bone Mineral Density) after 1 year, compared to women using HST (hormone replacement therapy).
The probability of a decrease in BMD increases with NTx value. Baseline NTx Probability of decrease in BMD18-38
1.4 p = 0.28
38-51 2.5 p = 0.03
51-67 3.8 p = 0.0006
67-188 17.3 p = 0.0001
2. Menopausal women receiving antiresorptive therapy (osteoporosis drug treatment): The probability of treatment being effective after three months is increased when the measured NTx value has decreased more than 30% from the first measurement.
3. Patients with Paget's bone disease
:The likelihood of treatment being effective after one month is greater when the measured NTx value is within is the reference range, or NTx has decreased by more than 30%
94.6 - 315 µg / g Crea♂
87.5 - 247 µg / g Crea
Measurement Method Used: High-Performance-Liquid-Chromatography (HPLC)
For Diagnosis and follow-up, therapy monitoring in increased bone resorption (osteoporosis) and increased cartilage degradation.
An elevated result indicates: bone and cartilage degradation in osteoporosis, hyperparathyroidism, hyperthyroidism, Paget's disease, bone metastases, therapy with corticoids, physiological bone growth. Deoxypyridinoline is bone specific.
Paget's disease is an inflammatory-like condition of your bone that leads to deformation of your bone. The balance between bone production and bone breakdown is disturbed. Your bone is broken down faster than normal because of this. New bone is made, but it is sloppy and not as orderly as normal bone production. The new bone is softer and more brittle so it bends or breaks faster. Also, the new bone is larger than the original bone. You may have pain from the affected bone.
Paget's disease is a long-standing (chronic) bone disorder. The condition is named after Sir James Paget, who was the first to describe it.
most people, the condition occurs in the pelvis. Other common sites include:
- the bones of your back (the spine and sacrum)
- the bones of your head (the skull)
- The bones of your arms and legs.
In more than half of people with Paget's bone disease, more bones are affected at once, but the condition does not spread to other bones.
Especially over 55 years of
agePaget's bone disease occurs in about 3.5% of people over 55 years of age. It almost never occurs in people younger than 40. Slightly more men than women get the condition. Proper treatment is important to prevent the bone from becoming increasingly affected and to prevent additional problems.