Non-Ceruloplasmin-bound Copper Wilson disease

Must be collected at the lab (frozen).

This test measures the fraction of copper in the blood that is not bound to ceruloplasmin and thus freely available for exchange and transport. also called "Non-Ceruloplasmin bound copper" or "Free Cu fraction"

What does this test measure?
The Free Copper – REC test measures the level of free copper in the blood. This is the portion of copper that is not bound to ceruloplasmin and therefore circulates freely in the bloodstream. An elevated level may indicate copper accumulation in the body, while a decreased level may indicate a deficiency.

Why is this test important?
Copper is an essential trace element that plays a role in energy production, the formation of connective tissue, and the functioning of the nervous system. An imbalance in copper levels can cause serious health problems.

Who is this test suitable for?
This test is useful for people with a clinical suspicion of Wilson’s disease or other copper storage disorders. The test can also be used to supplement other measurements of copper status, such as ceruloplasmin and total copper in the blood.

Indications for this test
This test is primarily used when Wilson’s disease is suspected, a rare genetic disorder in which copper accumulates in the liver, brain, and other organs.

Symptoms that may indicate copper stacking disease are:

• Unexplained liver problems
• Neurological complaints (tremors, speech disorders)
• Psychiatric symptoms (anxiety, depression, behavioral changes)

How is the test performed?
Sample type: 2 mL of serum or 2 mL of whole blood

Blood draw: at a blood collection site

Transport: shipment Medical mail
Performance: The test is analyzed by a specialized and ISO 15189-accredited laboratory.
Reference values: Normal value: < 18.5%

This test is new as of February 2025

After ordering, you will receive clear instructions on blood collection and sample shipment.