SIBO bloated belly
Indican and Skatol are waste products that end up in the urine when the amino acid tryptophan is insufficiently broken down by bacteria in the intestines. Too much of these breakdown products is a sign for intestinal bacteria to cause putrefaction in the small intestine. This is called SIBO (Small Intestinal Bacterial Overgrowth) or SBOG (Small Bowel Overgrowth Syndrome).
Elevated values of Indican and Skatol may indicate:
- SIBO (Small Intestinal Bacterial Overgrowth)
- the development of cancer over time, for example the development of a plasmocyte
- the self-inflicted metabolic disease Phenylketonuria (PKU) which is already identified in babies by the heel prick.
- Tryptophan-rich diet (lots of meat)
- Bladder problems
- White tide (women)
- Bile dysfunction
- Hepatic impairment
- Renal impairment
An elevated reading of both Indican and Skatol indicates SIBO. An increased value of Skatol indicates SIBO with a hepatic load. This is often a case of a (past) viral load on the liver.
See also this blog and explanation about SIBO and the fodmap diet that can help here
SIBO is an overgrowth of colon bacteria in the small intestine. In a healthy system, there is a low concentration in the small intestine and a high concentration in the large intestine. This is because the small intestine is where the food is digested, the food is mixed with digestive juices and the nutrients are absorbed into the bloodstream. When bacteria enter and take over the small intestine, they disrupt the digestive process. The two processes that usually precede bacterial overgrowth are decreased gastric acid secretion and decreased motility of the small intestine. Once present, bacterial overgrowth can cause an inflammatory response in the intestinal lining, further exacerbating the typical symptoms of SIBO.
- Constipation Abdominal pain
- Abdominal cramps, often right after eating Bloating / distended belly Nausea
- Decrease in body weight Fatty liver
- Poor food digestion
- Malabsorption (especially of fat-soluble vitamins, zinc, manganese, magnesium, iron and
- vitamin B12) Fatigue
- Foul-smelling stools, often light in colour Gas formation
- Joint pain
- Food intolerances
Causes of SIBO
- Intestinal infection
- Disturbed bowel function
- Decreased production of enzymes by the pancreas Chronic pancreatitis
- Decreased production of bile acids
- Decreased gastric acid (possibly by antacids) Intestinal surgery
- Alteration of the gastrointestinal tract such as surgery in which part of the stomach or the
- Large intestine removed by trauma
- Medication such as antibiotics and chemotherapy
- Conditions such as celiac disease, diabetes mellitus,
- Small bulges in the small intestine,
- Liver disease,
- Rheumatoid arthritis,
- Scleroderma autoimmune disease hardening of connective tissue,
- Hypothyroidism, hashimoto's disease
- Crohn's disease.