Vitamin D receptor polymorphism
VDR-Gen-Polymorhismus blood test (VDRPC EDTA 5 ml.)
PCR testing for osteoporosis risk.
This blood test can be done to find out if someone has a mutation in the VDR receptors. This can include high vitamin D active (1.25) and low D inactive (25-OH).
Calcium-rich Diet is essential for the development and maintenance of bone mineral mass. Vitamin D plays a fundamental role in the regulation of calcium. Genes influence vitamin D metabolism. Vitamin D receptor (VDR) functions are responsible for changes in skeletal growth.
Also, people with a gene mutation on VDR gene polymorphisms may be associated with high caries risk. Read more about this in this pubmed study:
in this study, this gene mutation is associated with insulin resistance and the response to vitamin d.
Vitamin D deficiency has been linked to many diseases. Genetic variations of the vitamin D receptor (VDR) gene also affect vitamin D production. The VDR is an intracellular receptor found in virtually all body cells. Upon activation by vitamin D, production is initiated.
The vitamin D status of great importance. The lower it is, the less activation of the VDR. Vitamin D deficiency is common in areas that are northern. Even a good vitamin D level may be insufficient in certain polymorphisms, resulting in a higher risk of numerous diseases.
High vitamin D levels may improve VDR function and reduce risk.
Vitamin D is actually a steroid hormone. In addition to calcium metabolism, it is involved in the regulation of numerous hormonal, metabolic, neurological and (auto)-immune processes. This regulatory role arises primarily through the initiation of DNA transcripts in the cell nucleus. Vitamin D can be made 80 percent in the body under the influence of ultraviolet light.