TNF-alpha (tumor necrosis factor-alpha)
TNF-alpha (tumor necrosis factor-alpha) serum blood collection only at laboratory Monchengladbach. Cannot be collected at a puncture site.
Tumor necrosis factor-alpha (abbreviated TNFα, also called cachexin or cachectin) is one of two known tumor necrosis factors and a cytokine. It plays an important role in inflammatory processes and the acute-phase response.
TNF-alpha (tumor necrosis factor-alpha) from serum is a specialized test that can only be collected directly at the laboratory.
TNFα stimulates the inflammatory response in the body. This allows it to kill tumor cells. However, it also plays a key role as a messenger in rheumatoid arthritis and Crohn's disease. It increases inflammation. This results in tissue death (= necrosis). It is also responsible for disease manifestations outside of the joints, such as fatigue, emaciation, anemia, etc.
Overproduction of TNFα is associated with a number of diseases, including cancer. This is because TNFα activates by binding to Tumor Necrosis Factor receptor 1 (TNFr1) or Tumor Necrosis Factor receptor 2 (TNFr2).
There are a number of anti-TNFα drugs on the market. These substances neutralize TNFα so that the inflammatory process is inhibited.
The predisposition for cachexin lies on chromosome 6 of the human genome.
This test is only available upon request from a physician, a signed consent form and the name of the practitioner must be submitted when ordering.