Liver diseases combo: ALT, AST and Gamma GT
Investigations for liver disease, liver problems or to detect excessive alcohol consumption.
The following tests are performed:
- Gamma-GT (GGT)
- ALAT (GPT)
- ASAT (GOT)
Strength training can lead to elevated liver values in blood tests. This applies specifically to ASAT and ALAT. This is not because strength training is stressful for the liver, but because muscle breakdown causes these enzymes to enter the blood in increased levels. These elevated values can last up to twelve days after strength training. Therefore, it is recommended that power athletes do not train internally for at least ten days before the liver ASAT and ALAT values are measured. This is the only way to get a reliable picture of these values in relation to the function of the liver and alcohol consumption.
(GGT) is an enzyme that is made in the liver and helps with the conversion and digestion of substances that enter the body through food and drink. Normally, the concentration of GGT in the blood is very low, but when the liver is under heavy stress, the amount can rise considerably. This happens when the liver is supplied with a lot of substances to process in a short period of time, for example with (extreme) use of medicines or alcohol. GGT will also rise when the bile ducts are blocked, with gallbladder problems, or as a result of liver damage.
An enzyme is a protein that helps cells convert a certain substance into another substance. ALAT is present primarily in the liver. Smaller amounts are found in the kidneys, heart, and muscles. Normally, the amount of ALAT in the blood is low. When liver cells are damaged, ALAT leaks from the liver into the blood. As a result, the amount of ALAT in the blood rises. This can happen before there are any symptoms or signs (such as jaundice, yellow eyes, or yellow skin) that indicate liver damage.
The test also determines the amount of the enzyme aspartate aminotransferase (ASAT) in blood. An enzyme is a protein that helps cells convert one substance into another. ASAT is present mainly in the liver and in transverse muscle tissue (heart and skeletal muscle). Normally, the amount of ASAT in the blood is low. When liver or muscle cells are damaged, ASAT is released into the blood.